Iodine-Dimethyl sulfoxide Promoted Synthesis of Novel TetracyclicThiazolo[3',2':2,3]pyrido[4,5-d]pyrido[1,2-a]pyrimidinones

Onychomycosis treated with a dilute povidone–iodine/dimethyl sulfoxide preparation

BACKGROUND Povidone-iodine (PVP-I) 10% aqueous solution is a well-known, nontoxic, commonly used topical antiseptic with no reported incidence of fungal resistance. We have been using a low-dose formulation of 1% PVP-I (w/w) in a solution containing dimethyl sulfoxide (DMSO) in our clinical practice for a variety of indications. Presented here is our clinical experience with this novel formulat...

Low temperature synthesis of ionic phosphates in dimethyl sulfoxide.

A new synthesis route for phosphates in an organic solvent at low temperatures is presented. The synthesis was done by dispersing a nitrate salt and phosphorus pentoxide in dimethyl sulfoxide. The synthesis can be performed under water-free conditions and yielded several organic and inorganic phosphates. Crystal structure solution of bistetramethylammonium hydrogencyclotriphosphate, [N(CH3)4]2H...

Synthesis of Cyclopropanated Dimethyl Mercaptal Sulfoxide Pyranoses from Epoxytriflate Pyranosides and Methyl Methylthiomethyl Sulfoxide

Stereospecifically cyclopropanated sugar deriva­ tives are not only interesting from their biological point of view, but they can also serve as templates for the synthesis of natural products using the chiron approach [1]. The previous successes in the synthesis of a number of cyclopropanated sugar derivatives via diplacement of the triflyl group [2] promoted us to investigate a similar reactio...

DFT study of dimers of dimethyl sulfoxide in gas phase

Density functional (DFT) calculations at M05-2x/aug-cc-pVDZ level were used to analyze the interactions between dimethyl sulfoxide (DMSO) dimers. The structures obtained have been analyzed with the Atoms in Molecules (AIMs) and Natural Bond Orbital (NBO) methodologies. Four minima were located on the potential energy surface of the dimers. Three types of interactions are observed, CH•••O, CH•••...

Clinical Considerations of Dimethyl Sulfoxide